Cliffs: 645 subjects were split into four groups that varied macronutrient composition, but each was in a 750 calorie deficit.
The diets were based on percentage of calories (fat/carbohydrate/protein)
Group 1 – 20/15/65
Group 2 – 20/25/55
Group 3 – 40/15/45
Group 4 – 40/25/35
Despite a wide variety of macronutrient composition, there was no significant difference in weight loss between groups.
Take home point: Calories are the main culprit of weight loss or gain. For long term success it's ideal to find a macronutrient composition that's most easily adhered to for each individual.